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DOH Lab Assistant (DOHLA) Practice Tests & Test Prep by Exam Edge - Review


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DOH Laboratory Assistant - Reviews


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Based on 185 reviews

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See why our users from 154 countries love us for their exam prep! Including 185 reviews for the DOH Lab Assistant exam.

Exam Edge is an industry leader in online test prep. We work with institutional partners to offer a wide array of practice tests that will help you prepare for your big exam. No matter how niche your field of interest might be, we're here to help you prepare for test day.

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DOH Laboratory Assistant - Test Reviews Sample Questions

The adult leukemia that shows a notched or dumbbell-shaped nucleus and is a rare B-cell disease characterized by lymphocytopenia is which of the following?

Correct Answer:
hairy cell leukemia


hairy cell leukemia (hcl) is a rare form of chronic leukemia that affects b lymphocytes, a type of white blood cell responsible for producing antibodies. this malignancy is most commonly diagnosed in middle-aged or elderly individuals, typically seen in patients over the age of 50. one of the hallmark features of hcl is lymphocytopenia, which is a condition characterized by an abnormally low count of lymphocytes in the blood.

the disease gets its name from the appearance of the cancer cells, which display fine, hair-like projections when viewed under a microscope. these projections are actually cytoplasmic extensions that make the cells easily recognizable. another distinctive feature of hcl cells is their nucleus, which often appears notched or dumbbell-shaped. these morphological characteristics are critical for the diagnosis of hcl and help differentiate it from other types of leukemia.

clinically, hcl leads to severe spleen enlargement (splenomegaly) due to the accumulation of malignant cells. this can cause discomfort or pain in the left upper quadrant of the abdomen. patients may also experience fatigue, weight loss, and frequent infections due to the reduction in normal blood cell production and the resultant compromised immune system.

treatment for hcl has evolved significantly over the years and now often includes the use of purine analogs such as cladribine or pentostatin, which have shown high rates of disease remission. biological therapies that target specific cellular pathways are also being used. despite its chronic nature, with appropriate treatment, many patients achieve a good quality of life and a normal or near-normal life expectancy.

in summary, hairy cell leukemia is a distinct type of leukemia notable for its unique cell morphology, including a notched or dumbbell-shaped nucleus and hair-like cytoplasmic projections. it primarily affects older adults and leads to symptoms related to spleen enlargement and low blood cell counts. effective treatments are available, making hcl a manageable condition for many patients.

In terms of HLA nomenclature, which of the following statements is false?

Correct Answer:
in the hla antigen hla-a2, the a is the allele and the 2 is the locus.


human leukocyte antigens (hla) are molecules displayed on cell surfaces that play a crucial role in immune system regulation, particularly in the recognition of foreign molecules by the immune system. the naming of these antigens follows a specific nomenclature that reflects the genetic loci and specific alleles responsible for their production.

hla antigens are named according to the product expressed by the gene locus and the allele. for example, in the hla antigen hla-a2, "hla" stands for human leukocyte antigen, indicating that this is a human cell surface antigen involved in immune response. the "a" in hla-a2 represents the gene locus. the hla gene complex on chromosome 6 is organized into several loci, with a, b, c, d, dr, dq, and dp being the most notable. each locus can produce several different antigens, depending on the allele present.

the "2" in hla-a2 represents the allele at the a locus. alleles are different versions of a gene that arise due to mutations and can produce slightly different proteins. in the context of hla, different alleles encode for antigens that can vary slightly in structure. these structural variations can influence how effectively an antigen presents peptide fragments to immune cells, impacting the immune response.

therefore, the statement "in the hla antigen hla-a2, the a is the allele and the 2 is the locus" is incorrect. it mislabels the components of the hla naming system, swapping the designations for the locus and the allele. understanding this nomenclature is crucial for clinicians and researchers in transplant medicine, immunology, and related fields, as it helps in matching organ donors with recipients and understanding immune responses to pathogens and diseases.