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Correct Answer: any of the above
cholestyramine, a bile-acid sequestrant, is commonly used to lower cholesterol levels by binding bile acids in the intestine. this prevents the reabsorption of bile acids into the bloodstream, thus forcing the liver to use excess cholesterol to produce more bile acids. this process helps reduce the level of cholesterol in the blood, thereby benefiting patients with coronary artery disease, which is characterized by the buildup of cholesterol-laden plaques in coronary arteries.
for effective administration, cholestyramine should be mixed with a liquid or semi-solid food. it can be taken with water, which is the simplest and most straightforward method. mixing the powder with a sufficient amount of water ensures that it is diluted properly, which aids in swallowing and prevents the powder from sticking to the mucous membranes of the esophagus, potentially causing irritation.
alternatively, cholestyramine can be administered with fruit juice. this not only aids in diluting the powder but also improves the taste, making the medication more palatable. the acidity and natural sugars in fruit juice can help mask the unpleasant taste of cholestyramine, which some patients might find off-putting if mixed with water alone.
the medication can also be mixed with pulpy fruits such as applesauce or mashed bananas. the texture of these fruits helps in blending the powder thoroughly, ensuring that it does not clump or stick, which could lead to irritation of the digestive tract. additionally, the natural sweetness and flavors of the fruits can help improve the taste.
another option for administering cholestyramine is mixing it with soup. this is particularly useful for patients who may want a more savory option instead of sweet. warm soup can help in dissolving the powder effectively, and the fluid content ensures proper hydration, which is crucial since cholestyramine can be dehydrating.
regardless of the chosen medium for administration, it is important to increase fiber intake while on cholestyramine. the medication can cause constipation due to its mechanism of binding bile acids, which also helps in stool formation. adequate fiber intake ensures normal bowel movements and reduces the risk of constipation. this can be achieved through dietary adjustments or by using fiber supplements.
in conclusion, cholestyramine can be administered with any of the above-mentioned mediums—water, fruit juice, pulpy fruits, or soup. each method ensures that the medication is taken in a way that minimizes discomfort, enhances palatability, and supports overall digestive health. adjustments in dietary fiber intake are also crucial for managing potential side effects and enhancing the efficacy of the treatment for coronary artery disease.
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