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DHA Pharmacology - Test Reviews Sample Questions

In 1968, a drug was found serendipitously to treat Parkinson’s disease while actually being used as an influenza A prophylaxis. This medication would be considered which of the following?





Correct Answer:
amantadine
the correct answer is *amantadine.*

amantadine was originally developed and used as an antiviral agent for the prophylaxis and treatment of influenza a in adults. however, in a surprising and serendipitous discovery in 1968, it was observed to offer therapeutic benefits for patients suffering from parkinson's disease. this unexpected benefit came to light when patients being treated for influenza with amantadine exhibited noticeable improvements in symptoms related to parkinson’s disease, such as rest tremor, akinesia (loss or impairment of voluntary movement), and rigidity.

the mechanism by which amantadine benefits parkinson’s disease patients is thought to be through its influence on the dopaminergic system. although it doesn’t increase dopamine levels directly, it is believed to increase the release of dopamine and block the reuptake of dopamine into neurons, thus increasing dopamine availability in certain areas of the brain. this mechanism helps in alleviating the motor symptoms associated with parkinson’s disease.

following this discovery, the use of amantadine was extended beyond just an antiviral drug. it became a recognized treatment option for managing symptoms of parkinson’s disease, particularly in the earlier stages of the condition. it is also used to manage drug-induced extrapyramidal symptoms, common side effects of certain psychiatric drugs that affect the nervous system similarly to parkinson’s disease.

to this day, amantadine continues to be utilized both as an antiviral agent against influenza a and as a valuable medication in the treatment of parkinson’s disease and related movement disorders. this dual use underscores the importance of serendipitous discoveries in the medical field, where a drug intended for one purpose may find an equally or more valuable application in a completely different area.

All of the following would be included as a side effect of folic acid except?





Correct Answer:
hypercalcemia
the question requires identifying which side effect is not commonly associated with the use of folic acid. folic acid, also known as vitamin b9, is crucial for numerous bodily functions, particularly in aiding rapid cell division and growth, and in the production of dna and rna. it is especially important during periods of rapid growth, such as during pregnancy and fetal development.

folic acid supplements are generally well tolerated, but like all medications and supplements, they can have side effects. common side effects of folic acid include gastrointestinal issues such as diarrhea and abdominal cramps, as well as other reactions like rash, sleep disorders, confusion, behavior changes, and excitability. these side effects are relatively rare and generally mild if they do occur.

among the options provided (diarrhea, hypercalcemia, rash, stomach upset), hypercalcemia stands out as the least likely side effect of folic acid. hypercalcemia refers to an abnormally high level of calcium in the blood. this condition is typically not related to the intake of folic acid. instead, hypercalcemia can be caused by other conditions such as hyperparathyroidism, cancer, excessive use of calcium supplements, or certain diuretic medications.

diarrhea and stomach upset are gastrointestinal side effects that can occur with many supplements and medications, including folic acid, due to their impact on the digestive system. a rash can be a potential allergic reaction to folic acid or an additive within the supplement formulation.

therefore, the correct answer is hypercalcemia, as it is not a known side effect of folic acid supplementation. understanding the typical side effects associated with supplements can aid in better managing and anticipating potential reactions, ensuring safer and more effective use of these health aids.