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DHA Pharmacology Practice Exams & Test Questions - Review



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See why our users from 154 countries love us for their exam prep! Including 100 reviews for the DHA Pharmacology exam.

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DHA Pharmacology - Test Reviews Sample Questions

In 1968, a drug was found serendipitously to treat Parkinson’s disease while actually being used as an influenza A prophylaxis. This medication would be considered which of the following?

Correct Answer:
amantadine
the correct answer is *amantadine.*

amantadine was originally developed and used as an antiviral agent for the prophylaxis and treatment of influenza a in adults. however, in a surprising and serendipitous discovery in 1968, it was observed to offer therapeutic benefits for patients suffering from parkinson's disease. this unexpected benefit came to light when patients being treated for influenza with amantadine exhibited noticeable improvements in symptoms related to parkinson’s disease, such as rest tremor, akinesia (loss or impairment of voluntary movement), and rigidity.

the mechanism by which amantadine benefits parkinson’s disease patients is thought to be through its influence on the dopaminergic system. although it doesn’t increase dopamine levels directly, it is believed to increase the release of dopamine and block the reuptake of dopamine into neurons, thus increasing dopamine availability in certain areas of the brain. this mechanism helps in alleviating the motor symptoms associated with parkinson’s disease.

following this discovery, the use of amantadine was extended beyond just an antiviral drug. it became a recognized treatment option for managing symptoms of parkinson’s disease, particularly in the earlier stages of the condition. it is also used to manage drug-induced extrapyramidal symptoms, common side effects of certain psychiatric drugs that affect the nervous system similarly to parkinson’s disease.

to this day, amantadine continues to be utilized both as an antiviral agent against influenza a and as a valuable medication in the treatment of parkinson’s disease and related movement disorders. this dual use underscores the importance of serendipitous discoveries in the medical field, where a drug intended for one purpose may find an equally or more valuable application in a completely different area.